Are there any good places to kind of figure out how to lay it out? I think I'll still need to be semi-mobile in case we need to put one of our vehicles in the garage, but I doubt we'll ever put 2 in it.
Shops evolve, and it is really difficult to get it perfect the first time around. Tool placement is important, but that's the easy thing to change if you don't like the setup. There are four things you want to do up front:
(1) Electrical. Get a bunch of outlets. If you plan to use 240V tools, add at least one 240V on every wall. It's helpful to have multiple sockets on different circuits next to each other so you can plug in a router into one and the dust collector in the one beside it. I have 42 outlets on 10 circuits and I honestly believe I have finally discovered the Question to the Answer about Life, the Universe, and Everything ("How many outlets should a shop have for a woodworker to be happy?")
Surface mounted conduit allows for some flexibility in layout over time. I used it in my shop. In retrospect, I should have just cut a trench in the drywall and ran Romex. It's cheaper and much faster than learning how to bend conduit. More importantly, the conduit takes up space. Also, I put the outlet boxes where there were studs to screw into. That limits where you can hang things like cabinets, lumber racks etc. But it does look very industrial, and when I upgraded my table saw it was easy to replace the 12 gauge with 10 gauge wire.
(2) Flooring. Once the tools and cabinets are in, you'll never get around to flooring. I really like the Dricore product Ken recommended. If I ever redo my floor, I will use that or some sort of oak strip flooring you can put over concrete. Much easier to stand on for longer periods of time, and the insulation factor is big.
(3) Lights. Think about how many 4ft bulbs you want, then double it. Now is the time to do it when you have easy access and can move a ladder around
(4) Paint. Offwhite is boring, but it adds a ton of light to the space. Even better would be to put up some sort of wood paneling, but that's not cheap and also requires quite a bit of effort.