If I were to edge it, I would use dowels and glue because this is what I've see used in my furniture repairing days. I've not seen any manufactured furniture use biscuits, not saying it's not out there I just haven't seen it, it's been doweled.
*If* they would have had access to biscuits in the old days they would have gladly used them. Biscuits are just a variation on the spline, which is itself a variation on the loose tenon -- just the same as a dowel. All provide for alignment assistance and improved joint strength.
Biscuits are seldom used in production setups not because they are in any way inferior but rather because they can not be cheaply or trivially jigged for in the same way a line boring machine can be for doweling. This is not a limitation for the DIYer, relatively few of whom own, or regularly use, a line boring machine. Once you own a good biscuit joiner you are likely to find it a go-to tool for it's ease of use and quick setup for such tasks where you want some alignment assistance or some additional strength above and beyond that of two glue faces (esp. where end grain constitutes one or both of those faces). The
PC 557 plate [biscuit] joiner even
supports a special mini-biscuit (FF size) ideally suited for joining especially narrow or thin materials where a typical #0 biscuit would be too large.
There is nothing wrong with any of the typical loose tenon solutions -- dowels, biscuits, or splines -- and
it is really a matter of personal opinion on the part of the builder. Even brads or finishing nails are acceptable if you don't mind filling the nail holes. Pocket hole screws are fine if the pocket holes can be adequately hidden, but often times that is not possible. If using pocket holes, it is a good idea to go ahead and glue the edge banding as well since the screws can create weaknesses in the banding that may result in future splitting (BTDT).
For thin edge banding masking tape or brads are sufficient for clamping (especially if a loose tenon was incorporated into the edge banding. However,
for thicker edge banding it is a good idea to
glue and clamp for maximum strength -- there are even
special 3-way C-Clamps designed specifically for applying edge banding in applications where traditional clamps might not be practical. You can either use a number of such clamps, or get by with just a few clamps per side if you incorporate a clamping caul. If you need the special C-clamps, I know Lowes carries the Bessey version (similar to below).
As others have mentioned, when using solid wood as your edge banding,
it is a good idea to slightly over-thickness the banding (by say 1/16" or thereabouts) so that it is slightly wider than the board edge it is being applied to -- with that excess thickness equally centered. You can then use a flush-trim (spiral or shear-cut flush-trims are ideal for this) router bit, hand planes, scrapers, or sanding to level the edge banding with the plywood it has been attached to.